Methoxetamine

Description

Buy Methoxetamine online.

Methoxetamine, or MXE, is a dissociative stimulant that has been marketed as a designer drug. Unlike other dissociatives such as ketamine and phencyclidine (PCP), which were originally developed as pharmaceutical anesthetics, MXE was specifically designed for distribution on the grey market. MXE is an arylcyclohexylamine that works mainly as anDA receptor antagonist, similar to other compounds in its class like ketamine and PCP. It specifically targets the dizocilpine (MK-801) site with high affinity (Ki = 257 nM) and produces effects similar to ketamine. Besides blocking NMDA receptors, MXE also acts as a serotonin reuptake inhibitor (Ki = 479 nM; IC50 = 2,400 nM), while showing little to no effect on dopamine and norepinephrine reuptake (Ki and IC50 > 10,000 nM). Still, it can boost dopaminergic activity, especially in the mesolimbic reward pathway—a trait shared with other NMDA antagonists like ketamine, PCP, and dizocilpine. Animal studies suggest MXE may have rapid antidepressant effects similar to ketamine. Screening across 56 receptor and transporter sites found MXE had Ki values >10,000 nM for all the dizocilpine site of the NMDA receptor and the serotonin transporter. MXE was designed in part to reduce the bladder toxicity seen with ketamine misuse, as its higher potency and lower dose were thought to limit toxic metabolite buildup. However, like ketamine, it has been shown to cause bladder irritation and fibrosis in mice at high, repeated doses, though human cases of urotoxicity have yet to be reported in the medical literature. Buy from SIGMA CHEMS USA at affordable rates. We offer the best research chemicals and deliver worldwide. All products are are discreetly packaged and shipped in discreet mode for our clients' privacy and security. We accept a variety of secure payment options and discounts for high volume purchases.